In November 2011, Yiannopoulos co-founded The Kernel.
In March 2013, The Kernel was shut down amidst allegations of unpaid wages, at a time when Yiannopoulos was the Editor-in-Chief and sole director of the parent company, Sentinel Media. It was reopened later that year under Kernel Media, with Yiannopoulos remaining Editor-in-Chief and having privately settled the previous debts. In 2014, The Kernel was acquired by Daily Dot Media, the parent company of The Daily Dot. After the acquisition by Daily Dot Media, Yiannopoulos stepped down as editor-in-chief, although he remained an adviser to the company.